The centre is based at UCD Conway Institute and consists of researchers in UCD and St Vincent’s and Mater University Hospitals. Our interdisciplinary research covers proteomics, computational biology, genetics, stratified medicines, sports and exercise, immunology/mechanisms of disease and animal models of RA.
Our centre has proven highly successful in developing translational experimental approaches including training and performance of mini-arthroscopy and tissue biopsy. The programme based across the UCD Clinical Research Centre, provides whole tissue biopsy explant cultures for research that is an entirely unique resource. Our teams’ ability to perform this research has led to both academic and industry collaborations attracting significant non-exchequer funding from both the EU and the US.
The expertise for this highly developed research programme has led to novel translational research outputs including presentations at the highest quality international research meetings and publication in high impact factor peer-review journals.
Click here to learn more about the Molecular Rheumatology Research Group, based in Trinity Biomedical Sciences Institute and led by Prof Ursula Fearon.
In the past decade or so, Th17 cells, have emerged as key players in autoimmune disease, as well as certain cancers and allergies. These potentially dangerous cells are normally regulated by endogenous mechanisms that include Treg cells, which serve to prevent autoimmunity. However in people who develop autoimmune disease, the regulation of Th17 cells goes awry, resulting in inappropriate and damaging inflammation. Dr Fletcher’s research career has focussed on understanding the role and regulation of Th17 cells in human diseases including MS, RA, psoriasis, cancer and hidradenitis suppurativa (HS), which is a debilitating yet under recognised skin disease. Importantly, studying the role of these cells in different diseases allows for greater understanding of common underlying mechanisms that can be translated to benefit for patients. The overarching research aim is to understand the role of Th17 cells in human disease and how they can be targeted to develop new or improved therapies.
Dr Carl Orr, Consultant Rheumatologist, with a specific interest in understanding molecular disease networks, particularly focusing on Rheumatoid Arthritis in relation to disease stratification, mechanisms and targets, incorporating both clinical and basic science foci. Dr Orr also has an interest in clinical management, and completed an MSc in Leadership and Management Development (Hons) at the Institute of Leadership at RCSI.
Dr Orla Killeen graduated from NUIG in 1996. She established the National Centre for Paediatric Rheumatology (NCPR) in 2006, providing care for patients with rheumatic and musculoskeletal disorders both on a local and national level. Dr Killeen does a joint adolescents transition clinic with prof Eamonn Molloy in SVUH. She also collaborates with Prof Ursula Fearon/Prof Douglas Veale, on immune cell responses and synovial pathology in children with arthritis associated downs arthropathy. Her area of interest include care of the Young person/Adolescent Rheumatology focusing in particular on Transition as well as juvenile idiopathic arthritis (JIA), Down’s Arthritis, juvenile dermatomyositis (JDM) and Auto-Inflammatory Syndromes.
Phil Gallagher is a Clinical Nurse specialist in Rheumatology SVUH, and is key to the coordination of clinical trials and the establishment of the biologic registries. Phil is critically involved at the interface between the clinical and basic science research teams, in relation to stratification, disease outcomes and potential new treatment strategies.
Phil also coordinates RABRI and ASRI, which are the National Rheumatoid Arthritis and AnkSpon registries. In addition, Phil coordinates the National Arthritis Research coalition (ARC).
Our work is focused on assessing inflammatory pathways driven by Osteoarthritis (OA)-associated alarmins or DAMPs (damage-associated molecular patterns). We are currently exploring the signalling events triggered by DAMPs in macrophages and synovial fibroblasts and have identified a number of molecules/pathways activated by OA-associated basic calcium phosphate crystals and S00A8/A9 proteins. We are also conducting a detailed study assessing the impact of traditional and novel orthopaedic implant materials on the host immune system, stem cell differentiation and tissue regeneration.
New Horizons in Rheumatology took place on Monday 12th & Tuesday 13th November 2018
The programme, which has been established through a number of partnerships with our European & US colleagues & the Centre for Arthritis and Rheumatic Diseases, seeks to deliver an educational forum which provides physicians, trainees and nursing colleagues with the opportunity to experience, review and discuss the key issues in Rheumatic and Musculoskeletal Diseases and novel therapies thereof.
The agenda for this meeting has been developed by an independent steering group of consultants.
Congratulations to Ms Megan Hanlon for winning best short scientific presentation and to the runners up Dr. Sarah Wade and Dr. Viviana Marzaioli.
Candice Lowe, MD, is a Rheumatology Newman Fellow current undertaking an MD by thesis. Dr lowe has research interests in needle arthroscopy, early arthritis, rheumatoid arthritis, prognostic markers, and B-cell targeted therapies.
Francis is a key member of the research team responsible for collecting, uploading and managing the clinical databases essential for many of the investigator initatied studies.
Candidate Advanced Nurse Practitioner based at The Rheumatic Musculoskeletal Disease Unit, Our Lady’s Hospice and Care Services, Harolds Cross.
Louise, former Clinical Nurse Specialist provides direct care to patients with complex arthritis related problems. She has completed an MSc in Rheumatology Reproductive
Medicine and founded the innovative Maternal Medicine Rheumatology clinic with colleagues at Holles St, National Maternity Hospital.
Research Assistant based at the Clinical Research Centre.
Gene provides essential support for the arthroscopy research programme and the specialised regional arthritis knee clinic. She provides valuable support to the clinical fellows, research nurses and the patients who attend for arthroscopy, follow-up and clinical assessment.
Research Nurse based at the Clinical Research Centre.
Edel has been intrinsic in the development of the arthroscopy research programme over the last 10 years. She provides valuable support to the clinical fellows, research nurses and the patients who attend for arthroscopy, follow-up and clinical assessment.
Research Nurse based at the Clinical Research Centre.
Hazel provides essential support for the arthroscopy research programme and the innovative RA clinical registry. She provides valuable support to the clinical fellows, research nurses and the patients who attend for arthroscopy, follow-up and clinical
Kieran Murray graduated from UCD Medical School in 2010. He is a fourth year specialist registrar and has previously worked in Mater Misericordiae University Hospital, Royal Perth Hospital, Beaumont Hospital and University College Hospital Galway. His main research interest is improving outcomes in inflammatory arthritis, through analysing biomarkers, infection risk and management in pregnancy.
Trudy obtained her BSc in Biomedical Health and Disease from University College Dublin in 2011. In the same year, Trudy was awarded a Molecular Medicine Ireland PhD scholarship for their unique cross-institutional Clinical and Translation Research Scholars Programme (CTRSP). During her PhD, she completed a four month Industry internship with Quintiles Transnational as part of the Global Regulatory Affairs department, providing regulatory ‘Roadmaps’ for large Pharma, advising them on the most efficient strategy to file a new drug application in Europe, South America and Asia. Trudy’s PhD research, entitled ‘Synovial inflammation in Rheumatoid Arthritis is regulated by Toll-like Receptor 2-activated signalling pathways’, was carried out in St. Vincent’s University Hospital and was completed in November 2015. Since this time, she has worked as a Postdoctoral researcher within the Molecular Rheumatology Group and Center for Arthritis and Rheumatic Diseases. At present, Trudy is the UCD Novartis Newman Postdoctoral Fellow and her research focuses on identifying the metabolic and cellular mechanisms that mediate inflammation in the joint. Her work is carried out in close collaboration with Industry partners including Janssen Pharmaceutics and Pfizer. She has received numerous travel grants to present her research within Europe and was awarded best oral presentation at both the MMI and New Horizons in Rheumatology national meetings. Trudy is the current Irish Country Lisiason Officer for EMEUNET (Emerging EULAR Network) and her role is to promote education and collaborative work among young clinicians and researchers in rheumatology and to liaise with other national representatives.
Prof Eamonn Molloy
Prof Eamonn Molloy is a Founder and Director of The Centre. Prof Molloy is a Consultant Rheumatologist at St. Vincent’s University Hospital and an honorary Professor at University College Dublin. His special interest is in the field of Vasculitis, especially Giant Cell Arteritis and Large Vessel Vasculitis, potentially serious systemic rheumatic diseases that cause inflammation of the circulation. Prof. Molloy provides a state-of-the-art clinical service for these patients, in addition to patients with inflammatory, degenerative and crystal-induced arthritis. He is the principal investigator on a number of active clinical trials and has led a number of translational and interventional innovative studies aimed at delivering novel therapies in these complex conditions
Dr Anne-Barbara-Mongey is a Member of the Board of The Centre, a Consultant Rheumatologist at St. Vincent’s University Hospital and a Lecturer at University College Dublin. Her special interest is in the field of arthritis connective tissue diseases, including systemic lupus erythematosus, potentially serious systemic rheumatic diseases. Dr. Mongey provides a state-of-the-art clinical service for these patients. In addition, as Lecturer in UCD she is deeply involved in teaching, organising and delivering the medical curriculum.
Richard Conway, MB PhD, is a rheumatologist and epidemiologist. He has research interests in rheumatoid arthritis, early arthritis, gout, medication-related adverse events, and in vasculitis, in particular giant cell arteritis. Richard has a particular methodological focus in the performance of systematic literature reviews and meta-analyses.
The Centre for Arthritis and Rheumatic diseases (SVUH, UCD) and Molecular Rheumatology (TCD) have developed a number of industry partnerships around drug discovery and translational research. These studies utilize the ex vivo whole tissue synovial explant model, sorted synovial cells and multiplex protein assays, transcriptomics and a systems biology approach to establish pre-clinical drug development studies of novel biotherapeutics and small molecular weight candidates.